Atazanavir / cobicistat

Phenobarbital

Contraindicated.

No pharmaceutical opinion available for this interaction.

Mechanism

Phenobarbital can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Atazanavir / cobicistat.

Atazanavir / cobicistat

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Risk of a possible development of resistance to antiretroviral class.

Recommendations

Alternative solution(s)

Phenobarbital

Pharmacodynamic effects

Unknown.

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

Tests

Atazanavir plasma level

Viral Load

CD4+

Pharmacokinetic parameters

Comment

Reference
  • 3230
    Atazanavir/cobicistat (Evotaz), Bristol-Myers Squibb, Québec, Canada, 8 septembre 2017.