https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14646

Darunavir / cobicistat

Glyburide

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / cobicistat can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Glyburide.

Darunavir / cobicistat

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Glyburide

Pharmacodynamic effects

Possible increase of the hypoglycemic effect.

Recommendations

Monitor for development of adverse effects and adjust dosage if necessary.

Alternative solution(s)

Metformin, DPP-4 Inhibitors, GLP-1 Agonists

Monitor

Signs and symptoms of hypoglycemia : headache, dizziness, tiredness, rapid heartbeat, nervousness, shakiness, nausea and sweating.

Tests

Blood Sugar

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3191
    Glyburide (Diabeta), Sanofi-Aventis, Québec, Canada, 24 novembre 2016.