https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14638

Darunavir / ritonavir

Glyburide

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Glyburide.

Darunavir / ritonavir can induce the metabolism (CYP 2C9) and decrease the plasma concentration of Glyburide.

Darunavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Glyburide

Pharmacodynamic effects

Possible increase of the hypoglycemic effect.

Possible decrease of clinical efficacy.

Pharmacodynamic effects difficult to predict.

Recommendations

Monitor the clinical efficacy and appearance of adverse effects.

Adjust dosage if necessary.

Alternative solution(s)

Metformin, DPP-4 Inhibitors, GLP-1 Agonists

Monitor

Signs and symptoms of hypoglycemia : headache, dizziness, tiredness, rapid heartbeat, nervousness, shakiness, nausea and sweating.

Tests

Blood Sugar

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3191
    Glyburide (Diabeta), Sanofi-Aventis, Québec, Canada, 24 novembre 2016.