https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14621

Ritonavir

Glimepiride

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Ritonavir can induce the metabolism (CYP 2C9) and decrease the plasma concentration of Glimepiride.

Ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Glimepiride

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy and adjust the dosage if necessary.

Alternative solution(s)

Metformin, DPP-4 Inhibitors, GLP-1 Agonists

Monitor

–

Tests

Blood Sugar

Pharmacokinetic parameters

–

Comment

Ref #3189 : Co-administration of 600 mg rifampicin, a CYP2C9 inducer, and a single dose of glimepiride 1 mg (after 7 days of once daily rifampicin 600 mg) resulted in a 34% in glimepiride AUC. However, no effect on blood glucose was observed in this study.

Reference
  • 3188
    Glimepiride (Amaryl), Sanofi-Aventis, Québec, Canada, 23 décembre 2016.
  • 3189
    Niemi M, Kivistö KT, Backman JT, Neuvonen PJ. Effect of rifampicin on the pharmacokinetics and pharmacodynamics of glimepiride. J Clin Pharmacol 2000; 50: 591-5.