https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14595

Ritonavir

Glicazide

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Ritonavir can induce the metabolism (CYP 2C9) and decrease the plasma concentration of Glicazide.

Ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Glicazide

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy and adjust the dosage if necessary.

Alternative solution(s)

Metformin, DPP-4 Inhibitors, GLP-1 Agonists

Monitor

–

Tests

Blood Sugar

Pharmacokinetic parameters

–

Comment

Ref #3187 : Co-administration of 600 mg rifampicin, a potent CYP2C9 inducer, and a single dose of glicazide 80 mg (after 7 days of once daily rifampicin 600 mg) resulted in a 70% in glicazide AUC.

Reference
  • 3186
    Gliclazide (Diamicron), Servier, Québec, Canada, 13 juillet 2016.
  • 3187
    Park JY, Kim KA, Park PW, Park CW, Shin JG. Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide. Clin Pharmacol Ther. 2003 Oct;74(4):334-40.