Darunavir / ritonavir

Glicazide

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir can induce the metabolism (CYP 2C9) and decrease the plasma concentration of Glicazide.

Darunavir / ritonavir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Glicazide

Pharmacodynamic effects

Recommendations

Monitor for clinical efficacy and adjust the dosage if necessary.

Alternative solution(s)

Metformin, DPP-4 Inhibitors, GLP-1 Agonists

Monitor

Tests

Blood Sugar

Pharmacokinetic parameters

Comment

Ref #3187 : Co-administration of 600 mg rifampicin, a potent CYP2C9 inducer, and a single dose of glicazide 80 mg (after 7 days of once daily rifampicin 600 mg) resulted in a 70% in glicazide AUC.

Reference
  • 3186
    Glicazide (Diamicron), Servier, Québec, Canada, 13 juillet 2016.
  • 3187
    Park JY, Kim KA, Park PW, Park CW, Shin JG. Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide. Clin Pharmacol Ther. 2003 Oct;74(4):334-40.