https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14569
No pharmaceutical opinion available for this interaction.
Ritonavir may induce the metabolism (UGT) and decrease the plasma concentration of Canagliflozin.
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Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
Consider increasing the dose to 300 mg in patients who tolerate canagliflozin 100 mg QD and with CrCl ≥ 60ml/min.
Metformin, DPP-4 Inhibitors, GLP-1 Agonists
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Blood Sugar
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Ref #3184 : Co-administration of 600 mg rifampicin, a potent UGT inducer, and a single dose of canagliflozin 300 mg (after 8 days of once daily rifampicin 600 mg) resulted in a 51% and 28% decrease in repaglinide AUC and Cmax, respectively.