https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14155
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14155
No pharmaceutical opinion available for this interaction.
Phenytoin may possibly induce the metabolism (CYP 3A4) and consequently decrease the concentration of Ritonavir.
Ritonavir may possibly induce the metabolism (CYP 2C9) and consequently decrease the concentration of Phenytoin.
Possible decrease of clinical efficacy.
Therefore, resulting in loss of therapeutic effect of associated IP.
Use this combination with caution.
Monitor for signs and symptoms of therapeutic failure.
An increase in dosage may be necessary.
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Possible decrease of clinical efficacy.
Avoid if possible. Use an alternative or monitor patient closely.
Monitor for signs and symptoms of therapeutic failure.
An increase in dosage may be necessary.
As clinically indicated : brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, pregabalin, rufinamide, topiramate, vigabatrin, zonisamide.
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Associated PI plasma level
CD4+
Viral load HIV
Phenytoin
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