https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14154

Cobicistat

Oxcarbazepine

Not recommended association.

No pharmaceutical opinion available for this interaction.

Mechanism

Oxcarbazepine may possibly induce the metabolism (CYP 3A4) and consequently decrease the concentration of Cobicistat.

Cobicistat

Pharmacodynamic effects

Possible decrease of the pharmacokinetic boosting effect.

Therefore, resulting in loss of therapeutic effect of associated IP.

Recommendations

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

–

Oxcarbazepine

Pharmacodynamic effects

–

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

–

Tests

Associated PI plasma level

CD4+

Viral load HIV

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3141
    Oxcarbazepine (Trileptal), Novartis, Québec, Canada, 18 mars 2015.
  • 2949
    Cobicistat (Tybost), European public assessment report (EPAR) Product Information, London, United Kingdom, 4 juin 2015.