Ledipasvir / Sofosbuvir

Dexlansoprazole

Administration time adjustment is recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Dexlansoprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of ledipasvir .

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

Dexlansoprazole

Pharmacodynamic effects

Recommendations

Give ledipasvir/sofosbuvir simultaneously with the proton-pump inhibitor. Proton-pump inhibitors should not be taken before taking ledipasvir/sofosbuvir.

Recommended dosage : doses comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.

Alternative solution(s)

Monitor

Tests

Heart rate

Pharmacokinetic parameters

Comment

See Lepidasvir/sofosbuvir + Omeprazole.

Equivalent doses to omeprazole 20 mg: dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.

Reference
  • 3073
    Ledipasvir/Sofosbuvir (Harvoni), Gilead, Ontario, Canada, 16 avril 2018.