https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14086
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14086
No pharmaceutical opinion available for this interaction.
Cobicistat can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Eletriptan.
–
–
–
Possible increase of adverse effects.
Contraindicated. Use alternative.
In patients already being treated with this combination and tolerating it, if deemed appropriate, keep actual treatment and exercise close monitoring of adverse effects.
Frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex) or zolmitriptan (Zomig)
Migraine symptoms and eletriptan adverse effects : chest tightness, vasoconstriction, hypertension, nausea, drowsiness and serotonin syndrome.
–
–
Ref #3122 : During a clinical trial, it was found that eletriptan Cmax and AUC were increased by about 3 to 6-fold respectively when this agent was administered with ketoconazole, and that eletriptan half-life stretched from 5 to 8 hours and Tmax from 2.8 to 5.4 hours.