https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=14058

Ledipasvir / Sofosbuvir

Lovastatin

Dosage adjustment may be necessary.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

DOWNLOAD
Mechanism

Ledipasvir may inhibit transports P-gp and/or BCRP and increase plasma concentration of Lovastatin.

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Lovastatin

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Use this combination with caution.

Use the lowest effective dose and titrate according to clinical response and occurrence of adverse effects.

Monitor closely.

Alternative solution(s)

–

Monitor

Symptoms of toxicity associated with hypolipidemic agents : gastrointestinal effects, fatigue and muscular weaknesses, myalgias, muscular cramps, myopathies, rhabdomyolysis and myoglobinuria leading to renal insufficiency.

Tests

Lipidic profile

CK

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3118
    Ledipasvir/sofosbuvir (Harvoni), European public assessment report (EPAR) Product Information, London, United Kingdom, 24 avril 2015.