Ledipasvir / Sofosbuvir

Phenytoin

Not recommended association.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Phenytoin may induce P-gp and decrease the plasma concentration of Ledipasvir / Sofosbuvir.

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Alternative solution(s)

Phenytoin

Pharmacodynamic effects

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

Gabapentin, pregabalin, valproic acid, clobazam, leviracetam, topiramate, lacosamide or lamotrigine.

Monitor

Tests

Pharmacokinetic parameters

Comment

Reference
  • 3073
    Ledipasvir/Sofosbuvir (Harvoni), Gilead, Ontario, Canada, 16 avril 2018.