https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13542
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADPhenobarbital may induce P-gp and decrease the plasma concentration of Ledipasvir / Sofosbuvir.
Possible decrease of clinical efficacy.
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Avoid association. Choose an alternative.
See comments.
Gabapentin, pregabalin, valproic acid, clobazam, leviracetam, topiramate, lacosamide or lamotrigine.
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Ref #3524 : Case report of five patients who received standard doses for the treatment of chronic hepatitis C infection while being maintained on first generation anticonvulsants (carbamazepine, phenobarbital, phenytoin). Four patients were treated with glecaprevir/pibrentasvir for 8 weeks and one patient with ledipasvir/sofosbuvir for 12 weeks. All five patients achieved a sustained virologic response (SVR) despite this drug interaction. The authors conclude that all efforts to prevent concomitant use with strong inducers should be made.