https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13507

Cobicistat

Phenytoin

Contraindicated.

No pharmaceutical opinion available for this interaction.

Mechanism

Phenytoin can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Cobicistat.

Cobicistat

Pharmacodynamic effects

Risk of a possible development of resistance to antiretroviral class.

Possible decrease of the pharmacokinetic boosting effect.

Therefore, resulting in loss of therapeutic effect of associated IP.

Recommendations

–

Alternative solution(s)

–

Phenytoin

Pharmacodynamic effects

–

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

–

Tests

Associated PI plasma level

Viral Load

CD4+

Pharmacokinetic parameters

–

Comment

–

Comment
Reference
  • 2949
    Cobicistat (Tybost), European public assessment report (EPAR) Product Information, London, United Kingdom, 4 juin 2015.
  • 3142
    Phenytoine (Dilantin), Pfizer, Québec, Canada, 22 juil 2013.