https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13506

Cobicistat

Phenobarbital

Contraindicated.

No pharmaceutical opinion available for this interaction.

Mechanism

Phenobarbital can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Cobicistat.

Cobicistat

Pharmacodynamic effects

Possible decrease of the pharmacokinetic boosting effect.

Therefore, resulting in loss of therapeutic effect of associated IP.

Risk of a possible development of resistance to antiretroviral class.

Recommendations

Avoid this association or monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

–

Phenobarbital

Pharmacodynamic effects

–

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

–

Tests

Associated PI plasma level

Viral Load

CD4+

Pharmacokinetic parameters

–

Comment

–

Reference
  • 2949
    Cobicistat (Tybost), European public assessment report (EPAR) Product Information, London, United Kingdom, 4 juin 2015.