Ledipasvir / Sofosbuvir

Digoxin

Use with caution.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

DOWNLOAD
Mechanism

Ledipasvir / Sofosbuvir can decrease the P-gp and increase the plasma concentration of Digoxin.

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Digoxin

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Use this combination with caution.

Monitor for development of adverse effects and adjust dosage if necessary.

Alternative solution(s)

Monitor

Adverse effects of digoxin: Gastrointestinal effects (abdominal discomfort, nausea/vomiting, diarrhea, anorexia, dyspepsia), central nervous system effects, vision disorders, fatigue, headache, bradycardia and rhythm disorders.

EKG

Tests

Digoxinemia

Pharmacokinetic parameters

Comment

Reference
  • 3073
    Ledipasvir/Sofosbuvir (Harvoni), Gilead, Ontario, Canada, 16 avril 2018.