https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13490

Ledipasvir / Sofosbuvir

Magnesium (hydroxide)

A spacing between the drugs is required.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Magnesium (hydroxide) by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of ledipasvir .

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Administer at least 4 hours before or after the antacid.

Monitor for clinical efficacy.

Alternative solution(s)

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Magnesium (hydroxide)

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

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Monitor

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Tests

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Pharmacokinetic parameters

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Comment

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Reference
  • 3073
    Ledipasvir/Sofosbuvir (Harvoni), Gilead, Ontario, Canada, 16 avril 2018.