No pharmaceutical opinion available for this interaction.
Phenytoin can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Darunavir / cobicistat.
3A4 (major) and 2D6 (minor)
3A4 (potent) and 2D6 (weak), P-gp, MATE 1, BCRP, OATP1B1 and OATP1B3.
Possible decrease of clinical efficacy.
Risk of a possible development of resistance to antiretroviral class.
Avoid this association or monitor for signs and symptoms of therapeutic failure.
1A2, 2B6, 2C9, 2E1, 3A4-7, UGT1A4, P-gp
Contraindicated. Use alternative.
Gabapentin, pregabalin, leviracetam.
Darunavir plasma level