https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13348
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13348
No pharmaceutical opinion available for this interaction.
Phenobarbital can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Darunavir / cobicistat.
Possible decrease of clinical efficacy.
Risk of a possible development of resistance to antiretroviral class.
Avoid this association or monitor for signs and symptoms of therapeutic failure.
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Contraindicated. Use alternative.
As clinically indicated : brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, pregabalin, rufinamide, topiramate, vigabatrin, zonisamide.
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Viral Load
Darunavir plasma level
CD4+
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