No pharmaceutical opinion available for this interaction.
Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Darunavir / cobicistat.
3A4 (major) and 2D6 (minor)
3A4 (potent) and 2D6 (weak), P-gp, MATE 1, BCRP, OATP1B1 and OATP1B3.
Possible decrease of clinical efficacy.
Risk of a possible development of resistance to antiretroviral class.
Monitor for signs and symptoms of therapeutic failure.
Cytosolic system, UGT
3A4, P-gp, UGT
2C19 (mostly if > 1200 mg/d)
Avoid association. Choose an alternative.
Gabapentin, pregabalin, leviracetam.
Darunavir plasma level
Viral load HIV