Dolutegravir

Cholestyramine

Administration time adjustment is recommended.

No pharmaceutical opinion available for this interaction.

Mechanism

Cholestyramine can bind to other medicines administered simultaneously and decrease their absorption .

Dolutegravir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Take 1 hour before or 4 to 6 hours after taking cholestyramine.

Monitor for clinical efficacy.

Alternative solution(s)

Cholestyramine

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Monitor

Tests

CD4+

Viral load HIV

Pharmacokinetic parameters

Comment

Since cholestyramine may bind to other drugs given concomitantly, the product monograph recommends other drugs be taken at least one hour before, or four to six hours after, the taking of cholestyramine.

Reference
  • 2799
    Cholestyramine (Olestyr), Pharmascience, Quebec, Canada, 7 février 2017.