No pharmaceutical opinion available for this interaction.
Magnesium (hydroxide) could bind (chelation) to raltegravir and reduce its absorption .
Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
Association not recommended with raltegravir 400 mg BID or raltegravir HD 1200 mg QD.
Calcium carbonate antacids with raltegravir 400 mg BID or H2 antagonists or inhibitors of proton pump receivers.
Raltegravir plasma level
Viral load HIV
Ref #2416 : Monograph recommends not to give raltegravir or raltegravir HD with antacids containing aluminum or magnesium. Antacids with calcium carbonate are not recommended with raltegravir HD and they also reduced raltegravir Cmin but this decrease is considered clinically non-significant.
See raltegravir + Aluminium/Magnesium hydroxyde and raltegravir + calcium (salts).