https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=11318
No pharmaceutical opinion available for this interaction.
Calcium (antacid) could bind (chelation) to elvitegravir and reduce its absorption .
Possible decrease of clinical efficacy.
The product monograph recommends to separate administration of elvitegravir and antacids by at least 2 hours.
Monitor for clinical efficacy.
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H2 receptor antagonists or proton pump inhibitors.
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Elvitegravir plasma level
CD4+
Viral Load
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Ref #2134 : When an aluminum and magnesium hydroxide 20 mL dose is given simultaneously with elvitegravir, elvitegravir AUC and Cmin decreased by 45% and 41%, respectively. While the antacid given 2 or 4 hours before elvitegravir or 2 or 4 hours after elvitegravir does not influence elvitegravir plasma concentration significantly.
For more details, see elvitegravir/cobicistat + aluminium/magnesium hydroxide.
See also elvitegravir/cobicistat + famotidine and elvitegravir/cobicistat + omeprazole.