https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=10989

Raltegravir

Cholestyramine

Administration time adjustment is recommended.

No pharmaceutical opinion available for this interaction.

Mechanism

Cholestyramine can bind to other medicines administered simultaneously and decrease their absorption .

Raltegravir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Take 1 hour before or 4 to 6 hours after taking cholestyramine.

Alternative solution(s)

–

Cholestyramine

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

Since cholestyramine may bind to other drugs given concomitantly, the product monograph recommends other drugs be taken at least one hour before, or four to six hours after, the taking of cholestyramine.

Comment
Reference
  • 2799
    Cholestyramine (Olestyr), Pharmascience, Quebec, Canada, 7 février 2017.