https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=10013

Rilpivirine

Esomeprazole

Contraindicated when taken orally.

No pharmaceutical opinion available for this interaction.

Mechanism

Esomeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of Rilpivirine.

Rilpivirine

Pharmacodynamic effects

Possible decrease of clinical efficacy and risk of possible development of resistance to antiretroviral class.

Recommendations

Avoid association.

Cabenuva : No anticipated interaction so no adjustments necessary.

Alternative solution(s)

Antiretroviral not influenced by gastric pH such as bictegravir, dolutegravir or doravirine.

Esomeprazole

Pharmacodynamic effects

–

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

See rilpivirine + famotidine and rilpivirine + antacids.

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

See rilpivirine + omeprazole.

Comment
Reference
  • 2598
    Rilpivirine (Edurant), Janssen, Ontario, Canada, 20 janvier 2023.
  • 2587
    Emtricitabine/Rilpivirine/Ténofovir DF (Complera), Gilead, Ontario, Canada, 17 octobre 2019.
  • 3441
    Dolutegravir/Rilpivirine (Juluca), ViiV Soins de santé ULC, Quebec, Canada, 5 juillet 2023.
  • 3460
    Rilpivirine/Emtricitabine/Tenofovir alafenamide (Odefsey), Gilead Sciences, Ontario, Canada, 13 novembre 2019.