Rilpivirine

Esomeprazole

Contraindicated.

No pharmaceutical opinion available for this interaction.

Mechanism

Esomeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of Rilpivirine.

Rilpivirine

Pharmacodynamic effects

Decreased clinical efficacy.

Risk of possible development of resistance to rilpivirine and other NNRTIs.

Recommendations

Avoid association.

Alternative solution(s)

Esomeprazole

Pharmacodynamic effects

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

See rilpivirine + famotidine and rilpivirine + antacids.

Monitor

Tests

Pharmacokinetic parameters

Comment

See rilpivirine + omeprazole.

Reference
  • 2598
    Rilpivirine (Edurant), Janssen, Ontario, Canada, 4 mars 2019.
  • 2587
    Emtricitabine/Rilpivirine/Ténofovir DF (Complera), Gilead, Ontario, Canada, 17 octobre 2019.
  • 3441
    Dolutegravir/Rilpivirine (Juluca), ViiV Healthcare ULC, Quebec, Canada, 19 août 2021.
  • 3460
    Rilpivirine/Emtricitabine/Tenofovir alafenamide (Odefsey), Gilead Sciences, Ontario, Canada, 13 novembre 2019.