https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=10009
No pharmaceutical opinion available for this interaction.
Omeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of Rilpivirine.
Decreased clinical efficacy.
Risk of possible development of resistance to rilpivirine and other NNRTIs.
Avoid association.
–
–
Contraindicated. Use alternative.
See rilpivirine + famotidine and rilpivirine + antacids.
–
–
Reference number |
---|
# patients |
HIV |
Dose |
Frequency |
AUC |
Cmax |
Cmin |
3555 |
---|
16 |
- |
150 mg * |
QD |
- 40 % |
- 40 % |
- 33 % |
3555 |
---|
15 |
- |
20 mg |
QD |
- 14% |
- 14% |
Ref #3555 : * The Interaction study has been performed with a dose higher than the recommended dose (25 mg QD) assessing the maximal effect on the coadministered drug.